对献血者进行IgA缺乏症筛查：对英格兰西南部献血人群的一项研究。
Screening of blood donors for IgA deficiency: a study of the donor population of south-west England.
作者信息
Holt P D, Tandy N P, Anstee D J
出版信息
J Clin Pathol. 1977 Nov;30(11):1007-10. doi: 10.1136/jcp.30.11.1007.
Abstract
Altogether 29 745 English blood donors were screened for IgA deficiency by double diffusion analysis; 57 had apparent absence of IgA, a frequency of 1:522. Further examination by the more sensitive haemagglutination inhibition assay revealed 34 samples having no detectable IgA, a frequency of 1:875. All donors negative by double diffusion analysis were tested for the presence of antibodies to IgA. Six class specific anti IgA antibodies and four anti IgA antibodies of limited specificity were detected. Three of these had the specificity anti alpha2 and one anti A2m(2). The 34 IgA deficient donors detected provide a source of IgA deficient blood for transfusion to patients with anti IgA antibodies.
摘要
通过双向扩散分析对总共29745名英国献血者进行了IgA缺乏筛查；57人明显缺乏IgA，频率为1:522。通过更灵敏的血凝抑制试验进一步检测发现，34份样本中检测不到IgA，频率为1:875。对所有双向扩散分析呈阴性的献血者检测其抗IgA抗体的存在情况。检测到6种类特异性抗IgA抗体和4种特异性有限的抗IgA抗体。其中3种具有抗α2特异性，1种具有抗A2m(2)特异性。检测到的34名IgA缺乏的献血者可作为缺乏IgA血液的来源，用于输注给有抗IgA抗体的患者。
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