Fialkow P J, Gilchrist C, Allison A C
Clin Exp Immunol. 1973 Apr;13(4):479-86.
F mice with chronic GVH disease were studied to investigate the hypothesis that non-specific stimulation of helper T cells, such as might be seen in graft-versus-host (GVH) disease, results in autoantibody production. Antinuclear antibody (ANA) was detected significantly more frequently in F mice with GVH disease than in control animals. The antigenic specificities of the ANA indicate that it is of host origin and, since it reacts with syngeneic nuclei, it can be considered a true autoantibody. The pattern of development, intensity, prevalence and sex distribution of ANA reactions differed notably in experiments with A × CBA Fs compared to those with C57B1/6 × BALB/c Fs suggesting that these parameters of ANA formation are influenced significantly by the genotype of the animal with GVH disease.
对患有慢性移植物抗宿主病（GVH病）的F小鼠进行了研究，以调查以下假设：辅助性T细胞的非特异性刺激，如在移植物抗宿主（GVH）病中可能出现的情况，会导致自身抗体产生。与对照动物相比，患有GVH病的F小鼠中抗核抗体（ANA）的检测频率显著更高。ANA的抗原特异性表明它起源于宿主，并且由于它与同基因细胞核发生反应，因此可以被认为是一种真正的自身抗体。与C57B1/6×BALB/c Fs的实验相比，A×CBA Fs的实验中ANA反应的发展模式、强度、患病率和性别分布有显著差异，这表明患有GVH病的动物的基因型对ANA形成的这些参数有显著影响。
