Velican D, Velican C
Acta Histochem. 1977;59(2):190-200. doi: 10.1016/S0065-1281(77)80039-1.
Investigations carried out on fetuses, children, adolescents and young adults showed that a particular histochemical pattern of the coronary intima glycosaminoglycans existed in each group of age. Beginning with childhood, a subendothelial "ground substance-rich layer" could be more clearly and constantly delineated in the thickened coronary intima. It exhibited a different chemical composition and macromolecular structural stability of its glycosaminoglycans as compared to those of the elastic hyperplastic and musculo-elastic layers. The presence of a "ground substance-rich layer" including dermatan sulfate and glycosaminoglycans resistant to hyaluronidases and chondroitinases appeared in our material as a prerequisite for the development of fatty dots and streaks. During the onset of fibrous plaques, the progressive blockade of the glycosaminoglycan acidic groups by basic proteins and the occurrence of numerous saline linkages between intimal macromolecular aggregates were the prevalent histochemical changes.
对胎儿、儿童、青少年和青年进行的调查显示，冠状动脉内膜糖胺聚糖的特定组织化学模式在每个年龄组中都存在。从儿童期开始，在增厚的冠状动脉内膜中可以更清晰、更稳定地勾勒出一个内皮下“富含基质层”。与弹性增生层和肌弹性层相比，它的糖胺聚糖表现出不同的化学成分和大分子结构稳定性。在我们的材料中，包括硫酸皮肤素和对透明质酸酶和软骨素酶有抗性的糖胺聚糖的“富含基质层”的存在似乎是脂肪点和条纹形成的先决条件。在纤维斑块形成过程中，碱性蛋白质对糖胺聚糖酸性基团的逐步阻断以及内膜大分子聚集体之间大量盐键的出现是主要的组织化学变化。
