Ylä-Herttuala S, Sumuvuori H, Karkola K, Möttönen M, Nikkari T
Lab Invest. 1986 Apr;54(4):402-7.
Glycosaminoglycans (GAGs) were studied in normal and atherosclerotic coronary arteries of 15- to 60-year-old Finnish men who had died accidentally. The GAGs were fractionated and quantified with electrophoretic techniques. The contents of sulfated GAGs (micrograms/cm2 vessel surface area) increased continuously until 20 to 30% of the vessel surface area was covered with fibrous plaques, after which they started to decrease. The largest increases were seen in chondroitin sulfates A and C and dermatan sulfate, the former of which rose earlier with lesion development. In normal coronary arteries the contents of dermatan sulfate and chondroitin sulfates A and C increased significantly with age, but the rises were much smaller than those found in affected vessels. The age-related changes in the percentage composition of GAGs in normal coronaries were qualitatively similar to those found in affected coronaries during lesion development. The alterations in arterial GAGs, therefore, seem to be related to two processes, both of which involve increased formation of connective tissue components by arterial smooth muscle cells: the normal growth and maturation of the vessels with a slow development of diffuse intimal thickening, and atherogenesis, which greatly increases the contents of sulfated GAGs in affected arteries.
对15至60岁意外死亡的芬兰男性的正常冠状动脉和动脉粥样硬化冠状动脉中的糖胺聚糖（GAGs）进行了研究。采用电泳技术对GAGs进行分离和定量。硫酸化GAGs的含量（微克/平方厘米血管表面积）持续增加，直至20%至30%的血管表面积被纤维斑块覆盖，此后开始下降。硫酸软骨素A和C以及硫酸皮肤素的增加最为明显，其中前者随着病变发展更早出现升高。在正常冠状动脉中，硫酸皮肤素以及硫酸软骨素A和C的含量随年龄显著增加，但增幅远小于病变血管中的增幅。正常冠状动脉中GAGs百分比组成的年龄相关变化在性质上与病变冠状动脉病变发展过程中的变化相似。因此，动脉GAGs的改变似乎与两个过程有关，这两个过程都涉及动脉平滑肌细胞结缔组织成分形成增加：血管的正常生长和成熟，伴有弥漫性内膜增厚的缓慢发展，以及动脉粥样硬化形成，后者极大地增加了病变动脉中硫酸化GAGs的含量。
