Dhikidze E K, Kavtaradze K N, Krilova R I, Rauss K, Kétyi I, Vertényi A
Acta Microbiol Acad Sci Hung. 1977;24(1):7-12.
Macaca mulatta monkeys were immunized orally with polyvalent Boivin extract of Shigella flexneri 2a, 3a, 4a, 4b, 6 and Shigella sonnei. The total immumizing dose for each component was equivalent to 1.2 X 10(12) cells. After challenge with 7.5 X 10(10) cells of a virulent S. flexneri 2a strain, out of 20 immunized animals 2 developed dysentery and 4 showed mild dyspepsia; all 6 control animals became ill with dysentery. Vaccination failed to influence the incidence, duration or the intermittent character of shigella excretion. Protective antibodies appeared in high titre in the serum of immunized animals.
用弗氏志贺菌2a、3a、4a、4b、6型及宋内志贺菌的多价博伊文提取物对猕猴进行口服免疫。每种成分的总免疫剂量相当于1.2×10¹²个细胞。在用7.5×10¹⁰个强毒弗氏志贺菌2a菌株攻击后，20只免疫动物中有2只发生痢疾，4只出现轻度消化不良；6只对照动物全部患痢疾。疫苗接种未能影响志贺菌排泄的发生率、持续时间或间歇性特征。免疫动物血清中出现了高滴度的保护性抗体。
