Mel D, Gangarosa E J, Radovanovic M L, Arsic B L, Litvinjenko S
Bull World Health Organ. 1971;45(4):457-64.
A field trial of oral streptomycin-dependent mutant Shigella vaccines in five hyperendemic areas of Yugoslavia in 1969 confirmed the findings of earlier studies by demonstrating the effectiveness of these vaccines against dysentery. For the first time, a high degree of protection was demonstrated in children. The vaccines induced serotype-specific immunity against Shigella flexneri 1 and 2a and S. sonnei. Postvaccinal reactions were minor and consisted of vomiting or diarrhoea, or both, in a small proportion of children within several hours of the administration of the vaccine. These reactions, seen mainly after the first dose, were dose-dependent and could be decreased by reducing the number of live organisms. Reactions to subsequent doses were much fewer. Pretreatment with sodium bicarbonate was necessary. Under the conditions of this study, the vaccines proved to be stable with no evidence of reversion of the mutant strains to the virulent parent.
1969年，在南斯拉夫五个痢疾高发地区对口服链霉素依赖型痢疾杆菌突变株疫苗进行的现场试验，通过证明这些疫苗对痢疾的有效性，证实了早期研究的结果。首次在儿童中证明了高度的保护作用。这些疫苗诱导了针对福氏志贺菌1型、2a型和宋内志贺菌的血清型特异性免疫。接种疫苗后的反应轻微，少数儿童在接种疫苗后数小时内出现呕吐或腹泻，或两者皆有。这些反应主要在首剂接种后出现，呈剂量依赖性，可通过减少活菌数量来减轻。后续剂量的反应则少得多。需要用碳酸氢钠进行预处理。在本研究条件下，这些疫苗被证明是稳定的，没有证据表明突变株回复为有毒力的亲本菌株。
