van Es L, Kwant-den Harink H, Pondman K W
Immunology. 1973 Jun;24(6):1087-97.
About 50 per cent of guinea-pigs immunized with egg albumin possess strong antibody activity in an immunoglobulin class with antigenic properties different from those of the well-known guinea-pig immunoglobulins. This immunoglobulin is present in normal guinea-pig serum in very small amounts and its concentration rises during immunization with egg albumin. Immunization with bovine insulin or bovine γ-globulin does not stimulate increased synthesis of this immunoglobulin class. Owing to the special conditions that are needed for its stimulation it is provisionally called IgS. It was found to be a heat stable 6.5S immunoglobulin and is not involved in PCA reactions.
用卵清蛋白免疫的豚鼠中，约50%在一种免疫球蛋白类别中具有强抗体活性，该类别具有与著名的豚鼠免疫球蛋白不同的抗原特性。这种免疫球蛋白在正常豚鼠血清中的含量极少，在用卵清蛋白免疫期间其浓度会升高。用牛胰岛素或牛γ球蛋白免疫不会刺激这种免疫球蛋白类别的合成增加。由于刺激它需要特殊条件，故暂称其为IgS。已发现它是一种热稳定的6.5S免疫球蛋白，且不参与PCA反应。
