Werblin T P, Kim Y T, Mage R, Benacerraf B, Siskind G W
Immunology. 1973 Jul;25(1):17-32.
A genetically diverse population of sixty-four rabbits has been studied with respect to the concentration and affinity of anti-DNP antibody produced over the course of a year following a single injection of DNP-BGG. It was found that the responses of male and female members of the population were essentially identical throughout the entire course of the immune response. The effect of allotype on the concentration and affinity of the antibody produced was examined. It was observed that the b6 allotype was associated with the production of decreased concentrations of antibody, the b5 allotype with the production of increased concentrations of antibody, the a1 allotype with the production of high affinity antibody and the a2 allotype with the production of low affinity antibody when compared to the remainder of the population. A tendency was also seen for individuals to maintain, over the course of time, their relative position in the population with respect to the concentration and affinity of the antibody they produce. Finally, it was observed that the mean affinity of the population continually shifted towards high affinity over the period of observation and that the standard deviation of the population with regard to the affinity of the antibody produced decreased with time.
对64只具有基因多样性的兔子进行了研究，观察在单次注射二硝基苯 - 牛γ球蛋白（DNP - BGG）后一年内产生的抗二硝基苯（anti - DNP）抗体的浓度和亲和力。结果发现，在免疫反应的整个过程中，该群体中雄性和雌性成员的反应基本相同。研究了同种异型对抗体产生的浓度和亲和力的影响。观察到，与群体中的其他兔子相比，b6同种异型与抗体浓度降低的产生相关，b5同种异型与抗体浓度升高的产生相关，a1同种异型与高亲和力抗体的产生相关，a2同种异型与低亲和力抗体的产生相关。还观察到，随着时间的推移，个体在群体中相对于其产生抗体的浓度和亲和力的相对位置有保持的趋势。最后，观察到在观察期内群体的平均亲和力持续向高亲和力转变，并且群体中关于所产生抗体亲和力的标准差随时间降低。
