疟原虫代谢中的辅助因子和维生素。除叶酸以外的因子。
Cofactors and vitamins in the metabolism of malarial parasites. Factors other than folates.
作者信息
Trager W
出版信息
Bull World Health Organ. 1977;55(2-3):285-9.
Abstract
Relatively few cofactors have so far been demonstrated to be essential for the intracellular development of erythrocytic stages of malarial parasites. Besides 4-aminobenzoic acid, presumably required for the synthesis of folates, these are biotin and pantothenate. The pantothenate is not used directly by the parasites but rather as coenzyme A synthesized by the host erythrocyte. Parasites maintained extracellularly in vitro also have a requirement for exogenous adenosine triphosphate. No information is available concerning cofactor requirements of the sporogonic or pre-erythrocytic stages.
摘要
到目前为止，相对较少的辅因子被证明是疟原虫红细胞内期在细胞内发育所必需的。除了推测用于叶酸合成的4-氨基苯甲酸外，这些辅因子还有生物素和泛酸盐。疟原虫并不直接利用泛酸盐，而是利用宿主红细胞合成的辅酶A。在体外细胞外维持的疟原虫也需要外源性三磷酸腺苷。关于孢子生殖期或红细胞前期的辅因子需求尚无相关信息。
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