黑眶蟾蜍黑色素生成过程中色氨酸吡咯酶与酪氨酸酶的相互关系

Interrelationship of tryptophan pyrrolase with tyrosinase in melanogenesis of Bufo melanostictus.

作者信息

Chakraborty D P, Chowdhury S K, Dey R N, Chatterjee A

出版信息

Clin Chim Acta. 1978 Jan 2;82(1-2):55-9. doi: 10.1016/0009-8981(78)90025-6.

Abstract

Tryptophan pyrrolase, a microsomal enzyme responsible for the break-down of tryptophan, has been detected in Bufo melanostictus. The enzyme has been found to be deactivated under influence of antivitiligo drug psoralene and activated by hydroquinone, an inhibitor of tyrosinase. Tryptophan pyrrolase has been found to have an antagonistic relationship with tyrosinase in Bufo melanostictus. The implication of the results has been discussed in relation to melanogenesis in vitiligo.

摘要

色氨酸吡咯酶是一种负责分解色氨酸的微粒体酶，已在黑眶蟾蜍中检测到。已发现该酶在抗白癜风药物补骨脂素的影响下失活，并被酪氨酸酶抑制剂对苯二酚激活。已发现色氨酸吡咯酶与黑眶蟾蜍中的酪氨酸酶存在拮抗关系。已结合白癜风中的黑素生成对结果的意义进行了讨论。