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哺乳动物酪氨酸酶——黑素细胞色素沉着的关键调控控制点。

Mammalian tyrosinase--the critical regulatory control point in melanocyte pigmentation.

作者信息

Hearing V J, Jiménez M

机构信息

Laboratory of Cell Biology, National Cancer Institute, Bethesda, MD 20892.

出版信息

Int J Biochem. 1987;19(12):1141-7. doi: 10.1016/0020-711x(87)90095-4.

DOI:10.1016/0020-711x(87)90095-4
PMID:3125075
Abstract
  1. Tyrosinase is a copper-containing enzyme responsible for the production of melanin pigment throughout the phylogenetic spectrum. 2. In mammals, tyrosinase is a glycosylated enzyme found specifically in melanocytes--cells functional in the production and secretion of pigment granules. 3. Although many factors determine the type, quantity and quality of the melanin produced, tyrosinase activity is the critical factor that ultimately regulates melanogenesis.
摘要
  1. 酪氨酸酶是一种含铜酶，在整个生物进化谱系中负责黑色素的生成。2. 在哺乳动物中，酪氨酸酶是一种糖基化酶，专门存在于黑素细胞中——黑素细胞在色素颗粒的产生和分泌中起作用。3. 尽管许多因素决定了所产生黑色素的类型、数量和质量，但酪氨酸酶活性是最终调节黑色素生成的关键因素。

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Mammalian tyrosinase--the critical regulatory control point in melanocyte pigmentation.哺乳动物酪氨酸酶——黑素细胞色素沉着的关键调控控制点。
Int J Biochem. 1987;19(12):1141-7. doi: 10.1016/0020-711x(87)90095-4.
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Regulation of tyrosinase in human melanocytes grown in culture.培养的人黑素细胞中酪氨酸酶的调控
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Regulation of mammalian melanogenesis by tyrosinase inhibition.通过抑制酪氨酸酶对哺乳动物黑色素生成的调控。
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Post-tyrosinase inhibition of melanogenesis by melatonin in hair follicles in vitro.褪黑素对体外毛囊黑素生成酪氨酸酶抑制作用后的研究
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Mammalian tyrosinase: biosynthesis, processing, and modulation by melanocyte-stimulating hormone.哺乳动物酪氨酸酶：生物合成、加工及促黑素细胞激素的调节
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Formation of melanin-tyrosinase complex and its possible significance as a model for control of melanin synthesis.黑色素 - 酪氨酸酶复合物的形成及其作为控制黑色素合成模型的可能意义。
Acta Derm Venereol. 1978;58(1):9-11.
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Pigment content of cultured human melanocytes does not correlate with tyrosinase message level.培养的人黑素细胞的色素含量与酪氨酸酶信息水平不相关。
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Comparison of tyrosinase levels in amelanotic and melanotic melanoma cell cultures by a competitive enzyme-linked immunoadsorbent assay and by immunotitration analysis.通过竞争性酶联免疫吸附测定和免疫滴定分析比较无色素性和色素性黑色素瘤细胞培养物中酪氨酸酶水平。
J Cell Physiol. 1988 Jan;134(1):149-54. doi: 10.1002/jcp.1041340119.
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Pathol Biol (Paris). 2000 Jul;48(6):577-83.

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