甲状腺功能正常的多结节性甲状腺肿对促甲状腺激素释放激素的反应及三碘甲状腺原氨酸抑制试验结果
Response to thyrotrophin-releasing hormone and triiodothyronine suppressibility in euthyroid multinodular goitre.
作者信息
Smeulers J, Docter R, Visser T J, Hennemann G
出版信息
Clin Endocrinol (Oxf). 1977 Nov;7(5):389-97. doi: 10.1111/j.1365-2265.1977.tb03348.x.
In twenty-two female patients with euthyroid multinodular goitre of varying size, thyroid suppression of 131I thyroid uptake by triiodothyronine (T3) and thyrotrophin (TSH) release after thyrotrophin-releasing hormone (TRH) administration were compared with thyroid weight, estimated by a planimetric method, and with serum thyroxine (T4) and T3 concentrations. Maximal increment of TSH (deltaTSH) after TRH and per cent T3-suppressibility were inversely related to thyroid weight and not related to basal serum T4 or T3 concentrations. deltaTSH and per cent suppression correlated positively, but deltaTSH was more often subnormal than T3-suppressibility. A practical consequence of our study is that nonconformity of the two tests may occur. This should be kept in mind in the evaluation of patients with thyroid disorders.
在22例患有不同大小的甲状腺功能正常的多结节性甲状腺肿的女性患者中，将三碘甲状腺原氨酸（T3）对131I甲状腺摄取的甲状腺抑制作用以及促甲状腺激素释放激素（TRH）给药后促甲状腺激素（TSH）的释放与通过平面测量法估算的甲状腺重量以及血清甲状腺素（T4）和T3浓度进行了比较。TRH给药后TSH的最大增加值（deltaTSH）和T3抑制百分比与甲状腺重量呈负相关，与基础血清T4或T3浓度无关。deltaTSH与抑制百分比呈正相关，但deltaTSH比T3抑制性更常低于正常水平。我们研究的一个实际结果是，这两种测试可能会出现不一致的情况。在评估甲状腺疾病患者时应牢记这一点。
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