Lauridsen U B, Kirkegaard C, Friis T, Siersbaek-Nielsen K
Acta Endocrinol (Copenh). 1975 Mar;78(3):461-7. doi: 10.1530/acta.0.0780461.
During antithyroid treatment a total of 88 TRH tests was performed in 56 clinical euthyroid patients. 56% had negative response to TRH (i.e. delta TSH smaller than 2 muU/ml) after being treated in average 12.6 months and no relation between the duration of treatment and the outcome of the TRH test was found. In the group with positive TRH tests (i.e. delta TSH greater than 2 muU/ml) the mean T4 value was slightly decreased (5.8 plus or minus SD 2.5 mug/100 ml) while the mean T3 value was normal (121 plus or minus SD 32 ng/100 ml). The group with negative TRH tests had quite normal serum T4 values (9.3 plus or minus SD 3.1 mug/100 ml) but in general high normal or elevated serum T3 values (175 plus or minus SD 31 ng/100 ml). Our results seem to indicate that serum T3 is of greater importance than serum T4 with regard to the outcome of the TRH test. The majority of the cases with negative TRH tests, however, had serum T3 and T4 values within normal range. In almost all patients with a negative TRH test a negative T3 suppression of 131I uptake in the thyroid gland was found while a positive TRH test was not correlated with suppressibility of 131I uptake.
在抗甲状腺治疗期间，对56例临床甲状腺功能正常的患者共进行了88次促甲状腺激素释放激素（TRH）试验。平均治疗12.6个月后，56%的患者对TRH试验呈阴性反应（即促甲状腺激素变化值小于2 μU/ml），且未发现治疗持续时间与TRH试验结果之间存在关联。在TRH试验呈阳性反应的组（即促甲状腺激素变化值大于2 μU/ml）中，平均T4值略有下降（5.8±标准差2.5 μg/100 ml），而平均T3值正常（121±标准差32 ng/100 ml）。TRH试验呈阴性反应的组血清T4值相当正常（9.3±标准差3.1 μg/100 ml），但血清T3值总体上处于高正常或升高水平（175±标准差31 ng/100 ml）。我们的结果似乎表明，就TRH试验结果而言，血清T3比血清T4更重要。然而，大多数TRH试验呈阴性反应的病例，其血清T3和T4值在正常范围内。在几乎所有TRH试验呈阴性反应的患者中，均发现甲状腺对131I摄取的T3抑制试验呈阴性，而TRH试验呈阳性与131I摄取的可抑制性无关。
