Fischer J T, Peter W
Dtsch Med Wochenschr. 1977 Dec 9;102(49):1808-13. doi: 10.1055/s-0028-1105603.
Folic acid concentration in plasma and erythrocytes and vitamin B12 concentration in plasma were determined by radioassay in 56 patients with chronic renal failure. Compensated retention was present in 31, while 25 were haemodialysed at regular intervals, 14 at home, and 11 in hospital. One patient had megaloblastic anaemia. Mean folic acid concentration in plasma for the whole group was 4.60 microgram/l (normal 8.30 +/- 2.57 microgram/l), in RBC 385 microgram/l (normal 459 +/- 143 microgram/l. Vitamin B12 levels were normal. These was no significant difference in folic acid levels betwwen patients on home or on hospital dialysis. During dialysis there was a fall in folic acid concentration in plasma which was proportional to the intial levels. After a four-week replacement pause folic acid concentration in RBC had not decreased in those patients on long-term dialysis who had previously received folic acid. The decreased folic-acid concentration in plasma of patients in compensated chronic renal failure is not due to the renal failure. Folic acid concentration in RBC is decisive in the assessment of folic acid deficiency.
采用放射分析法测定了56例慢性肾衰竭患者血浆和红细胞中的叶酸浓度以及血浆中的维生素B12浓度。31例存在代偿性潴留，25例定期进行血液透析，其中14例在家透析，11例在医院透析。1例患者患有巨幼细胞贫血。全组患者血浆叶酸平均浓度为4.60微克/升（正常为8.30±2.57微克/升），红细胞中为385微克/升（正常为459±143微克/升）。维生素B12水平正常。在家透析或医院透析的患者叶酸水平无显著差异。透析期间，血浆叶酸浓度下降，且与初始水平成比例。在为期四周的补充暂停期后，先前接受过叶酸治疗的长期透析患者红细胞中的叶酸浓度并未降低。代偿性慢性肾衰竭患者血浆中叶酸浓度降低并非由肾衰竭所致。红细胞中的叶酸浓度对评估叶酸缺乏起决定性作用。
