Iwangoff P, Enz A, Meier-Ruge W
Gerontology. 1978;24 Suppl 1:126-38. doi: 10.1159/000212306.
1 h after intravenous administration, 3H-DH-ergot alkaloids showed maximal uptake in the range of 10(-5)M in various visceral organs, and of 10(-7)M in most parts of the CNS of the cat. The clearance function in both groups of tissues was logarithmical linear, the slope of the straight line for the parts of the CNS being considerably flatter. Repeated administration of these drugs demonstrated a higher retention in the CNS than in the other organs. The single-dose level in the CNS is reinforced and, in contrast to liver and lung, maintained for at least 24 h.
静脉给药1小时后，3H - DH - 麦角生物碱在猫的各种内脏器官中的最大摄取量在10(-5)M范围内，在猫中枢神经系统的大部分区域为10(-7)M。两组组织中的清除功能呈对数线性，中枢神经系统各部分直线的斜率明显更平缓。重复给药表明这些药物在中枢神经系统中的滞留量高于其他器官。中枢神经系统中的单剂量水平得到增强，与肝脏和肺相反，至少维持24小时。
