Iwangoff P, Meier-Ruge W, Schieweck C, Enz A
Pharmacology. 1976;14(1):27-38. doi: 10.1159/000136576.
The distribution pattern of 3H-DH-ergotoxine, labelled by a direct hydration with tritium, was investigated in the cat brain. Apart from the pituitary gland, the brain shows an average DH-ergotoxine concentration of 10(-7) M. A 15% greater incorporation of DH-ergotoxine occurs in the cerebellum than in the cerebrum. In gradient centrifugation studies it is seen that 60% of the incorporated DH-ergotoxine is localized in the synaptosomal fraction. This finding seems to verify the microhistautoradiographic results of this investigation. The observation of a DH-ergotoxine binding in selected structures of the CNS , predominantly the synapses, could explain central nervous activities of DH-ergotoxine.
通过氚直接水合标记的3H - DH - 麦角隐亭在猫脑中的分布模式进行了研究。除垂体外，脑内DH - 麦角隐亭的平均浓度为10（-7）M。小脑对DH - 麦角隐亭的摄取比大脑多15%。在梯度离心研究中发现，摄取的DH - 麦角隐亭中有60%位于突触体部分。这一发现似乎证实了本研究的显微组织放射自显影结果。在中枢神经系统的特定结构（主要是突触）中观察到DH - 麦角隐亭的结合，这可以解释DH - 麦角隐亭的中枢神经活性。
