Koenuma M, Otake N
J Antibiot (Tokyo). 1977 Oct;30(10):819-28. doi: 10.7164/antibiotics.30.819.
Lysocellin is a new polyether antibiotic produced by Streptomyces cacaoi var. asoensis and is characterized as a broad spectrum ionophore having a higher complexation affinity for divalent cations than for monovalents and also having an ability to transport biological amines. The structures of two artifacts designated L1 and M1 have been elucidated based on spectral evidence, and the formation mechanism of these compounds was discussed with respect to the reactivity of the antibiotic. In addition, a number of degradation and modified products were prepared in order to examine their biological activity and to utilize as the model compounds for 13C-NMR assignment.
溶胞菌素是由可可链霉菌阿索变种产生的一种新型聚醚抗生素，其特点是作为一种广谱离子载体，对二价阳离子的络合亲和力高于单价阳离子，并且具有运输生物胺的能力。基于光谱证据阐明了两种命名为L1和M1的人工制品的结构，并就抗生素的反应性讨论了这些化合物的形成机制。此外，制备了许多降解和修饰产物，以检查它们的生物活性，并用作13C-NMR归属的模型化合物。
