离子载体类抗生素的研究。二十四。亮丝霉素，一种由吸水链霉菌产生的新型聚醚抗生素。
Studies on the ionophorous antibiotics. XXIV. Leuseramycin, a new polyether antibiotic produced by Streptomyces hygroscopicus.
作者信息
Mizutani T, Yamagishi M, Hara H, Kawashima A, Omura S, Ozeki M
出版信息
J Antibiot (Tokyo). 1980 Feb;33(2):137-43. doi: 10.7164/antibiotics.33.137.
PMID:7380724
Abstract
A new antibiotic leuseramycin has been isolated from the cultured mycelium of the strain of Streptomyces hygroscopicus TM-531. Physicochemical data, in particular those of 1H- and 13C-NMR spectra, revealed that leuseramycin is closely related to dianemycin in its structure, the former having a methyl group in place of the hydroxymethyl group at C-30. It is active against Gram-positive bacteria, some phytopathogenic fungi and some protozoa.
摘要
一种新的抗生素鲁塞尔霉素已从吸水链霉菌TM - 531菌株的培养菌丝体中分离出来。物理化学数据，特别是1H - 和13C - NMR光谱数据表明，鲁塞尔霉素在结构上与地恩霉素密切相关，前者在C - 30位有一个甲基取代羟甲基。它对革兰氏阳性菌、一些植物病原真菌和一些原生动物具有活性。
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