Spitz I M, Almaliach U, Rosen E, Polishuk W, Rabinowitz D
J Clin Endocrinol Metab. 1977 Dec;45(6):1173-8. doi: 10.1210/jcem-45-6-1173.
The hormonal response to luteinizing hormone releasing hormone (LHRH) thyrotropin releasing hormone (TRH) and chlorpromazine has been evaluated in eleven female subjects with the syndrome of isolated bihormonal gonadotropin deficiency (IGD). Following LHRH, all subjects had elevations of both LH and FSH, but the gonadotropin responses were attenuated relative to those observed in normal female subjects studied in the early proliferative phase of the cycle. Similarly, peak TSH levels after TRH were significantly less in subjects with IGD relative to normal controls. Basal prolactin levels were low in the patient group. Prolactin levels following TRH increased at least two-fold in control subjects and in the group with IGD. Conversely, chlorpromazine failed to induce elevations of prolactin in eight of nine females with IGD.
对11名患有单纯双激素促性腺激素缺乏症（IGD）综合征的女性受试者，评估了她们对促黄体生成素释放激素（LHRH）、促甲状腺激素释放激素（TRH）和氯丙嗪的激素反应。给予LHRH后，所有受试者的促黄体生成素（LH）和促卵泡生成素（FSH）均升高，但相对于在月经周期增殖早期研究的正常女性受试者所观察到的促性腺激素反应，这些患者的反应减弱。同样，IGD患者在给予TRH后的促甲状腺激素（TSH）峰值水平显著低于正常对照组。患者组的基础催乳素水平较低。给予TRH后，对照组和IGD组的催乳素水平至少升高两倍。相反，在9名IGD女性中，有8名对氯丙嗪无催乳素升高反应。
