Kaliner M, Austen K F
Science. 1974 Feb 15;183(4125):659-61. doi: 10.1126/science.183.4125.659.
An increase in adenosine 3',5'-monophosphate (cyclic AMP) in rat mast cells, achieved by stimulating the cells with prostaglandin E(1), by preventing cyclic AMP breakdown with aminophylline, or by adding exogenous dibutyryl cyclic AMP, prevented complement-mediated cytolysis as assessed by both histamine release and vital dye exclusion. Dibutyryl cyclic AMP also suppressed water-induced osmotic lysis.
通过用前列腺素E(1)刺激大鼠肥大细胞、用氨茶碱阻止环磷酸腺苷（cAMP）分解或添加外源性二丁酰环磷腺苷来提高大鼠肥大细胞中的3',5'-单磷酸腺苷（环磷腺苷）水平，经组胺释放和活体染料排斥评估发现，可预防补体介导的细胞溶解。二丁酰环磷腺苷还可抑制水诱导的渗透性溶解。
