人T淋巴细胞“E”花环功能。I. 一个受细胞内环磷酸腺苷调节的过程。
Human T lymphocyte "E" rosette function. I. A process modulated by intracellular cyclic AMP.
作者信息
Chisari F V, Edgington T S
出版信息
J Exp Med. 1974 Oct 1;140(4):1122-6. doi: 10.1084/jem.140.4.1122.
Abstract
The capacity of normal human T lymphocytes to form rosettes with sheep red blood cells can be inhibited by drugs or agents which induce elevations in intracellular levels of cyclic AMP. The effect is early in the presence of agents which elicit rapid elevations in intracellular cyclic AMP (isoproterenol, aminophylline) and occurs later in the presence of cholera toxin which induces a dalayed increase in endogenous cyclic AMP. Dibutyryl cyclic AMP is inhibitory, and the effects of dibutyryl cyclic AMP and the adenyl cyclase stimulators are potentiated by inhibition of phosphodiesterase. These data provide substantial evidence that elevation of intracellular cyclic AMP diminishes E rosette function of lymphocytes.
摘要
能够诱导细胞内环磷酸腺苷（cAMP）水平升高的药物或制剂，可抑制正常人T淋巴细胞与绵羊红细胞形成玫瑰花结的能力。对于能迅速引起细胞内cAMP升高的制剂（异丙肾上腺素、氨茶碱），这种作用出现得较早；而对于能引起内源性cAMP延迟升高的霍乱毒素，则作用出现得较晚。二丁酰环磷酸腺苷具有抑制作用，通过抑制磷酸二酯酶可增强二丁酰环磷酸腺苷和腺苷酸环化酶刺激剂的作用。这些数据提供了充分的证据，表明细胞内cAMP水平升高会减弱淋巴细胞的E玫瑰花结功能。
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