Palande D D, de Severy C, Rajagopalan M S
Lepr India. 1977 Jul;49(3):322-9.
39 consecutive cases of plantar ulcers with underlying chronic osteomyelitis admitted in the Sacred Heart Hospital during 1975/1976 were studied for the infecting organisms and their sensitivity to easily available antibiotics. Single organism was iasolated in only 10 cases, the infection in the rest being a mixed one. The commonest organisms were Staphylococcus, Streptococcus and Proteus mirabilis. In a few cases Pseudomonas and E-Coli were also isolated. Chloramphenicol was the most effective antibiotic in general and Streptomycin the least. 70% of the staphylococcus strains isolated were found to be resistant to Penicillin. Empirical use of antibiotics especially Penicillin and Streptomycin is hence deprecated.
对1975年至1976年间在圣心医院收治的39例伴有潜在慢性骨髓炎的足底溃疡病例进行了研究，以确定感染病原体及其对常用抗生素的敏感性。仅10例分离出单一病原体，其余病例感染为混合感染。最常见的病原体是葡萄球菌、链球菌和奇异变形杆菌。少数病例还分离出铜绿假单胞菌和大肠杆菌。总体而言，氯霉素是最有效的抗生素，链霉素最无效。分离出的葡萄球菌菌株中有70%对青霉素耐药。因此，不建议经验性使用抗生素，尤其是青霉素和链霉素。
