Crowley W R, Rodriguez-Sierra J F, Komisaruk B R
Psychopharmacology (Berl). 1977 Nov 15;54(3):223-5. doi: 10.1007/BF00426567.
Previous studies have suggested that in rats probing against the vaginal cervix with a glass of is analgesic, for this stimulus elevates the threshold for eliciting vocalization in response to tail shock. In the present studies pretreatment with naloxone HCl (1 or 10 mg/kg), a potent narcotic antagonist did not antagonize this vaginal stimulation-induced analgesia. Furthermore, vaginal stimulation was found to exert its analgesic effect even in rats made tolerant to, and dependent upon, morphine sulfate. These results suggest that the analgesic effect of vaginal stimulation is not necessarily mediated by an opiate-sensitive neural system. However, we hypothesize that even though vaginal stimulation and other analgesic manipulations may act via different neural substrates, they may nevertheless converge onto a final common mechanism for pain suppression.
先前的研究表明，在大鼠身上用玻璃棒刺激阴道宫颈具有镇痛作用，因为这种刺激会提高大鼠对尾部电击产生发声反应的阈值。在本研究中，用强效麻醉拮抗剂盐酸纳洛酮（1或10毫克/千克）进行预处理，并未拮抗这种阴道刺激诱导的镇痛作用。此外，即使在对硫酸吗啡产生耐受和依赖的大鼠中，阴道刺激也能发挥其镇痛作用。这些结果表明，阴道刺激的镇痛作用不一定由对阿片类敏感的神经系统介导。然而，我们推测，尽管阴道刺激和其他镇痛操作可能通过不同的神经基质起作用，但它们可能会汇聚到一个最终的共同疼痛抑制机制上。
