甲状腺疾病中某些氧化还原酶的细胞酶活性。

Cytoenzymologic activities of some oxidreductases in thyreopathies.

作者信息

Taşcă C, Stefăneanu L, Constantinescu S, Filipescu G

出版信息

Acta Histochem. 1977;60(1):58-66. doi: 10.1016/s0065-1281(77)80024-x.

Abstract

The authors studied in cryostat sections and in smears from thyroid aspirates the cytoenzymic pattern of the following thyreopathies: euthyroid goitre, GRAVES' disease, hyperthyroidized goitre, HASHIMOTO's thyroiditis and folliculo-papillary carcinoma. A biochemical study was simultaneously performed. According to the investigated thyreopathies the highest enzymic activity was found in the GRAVES' disease especially for peroxidase, glucose-6-phosphate dehydrogenase and succinate dehydrogenase. Lactate dehydrogenase showed a great activity in thyroid cancer. The lowest activity was found in the HASHIMOTO's thyroiditis with strong fibrosclerosis. The same pattern was found in thyroid smears from fine needle aspirates. The biochemical analysi revealed a strong parallelism with cytoenzymic results. The isozymic pattern of lactate dehydrogenase showed no significant differences between the thyreopathies.

摘要

作者通过对甲状腺冰冻切片和甲状腺细针穿刺涂片进行研究，分析了以下甲状腺疾病的细胞酶模式：甲状腺功能正常的甲状腺肿、格雷夫斯病、甲状腺功能亢进的甲状腺肿、桥本甲状腺炎和滤泡状乳头状癌。同时进行了生化研究。根据所研究的甲状腺疾病，发现格雷夫斯病中酶活性最高，尤其是过氧化物酶、葡萄糖-6-磷酸脱氢酶和琥珀酸脱氢酶。乳酸脱氢酶在甲状腺癌中活性很高。在伴有严重纤维化的桥本甲状腺炎中活性最低。在甲状腺细针穿刺涂片检查中也发现了相同的模式。生化分析结果与细胞酶学结果高度一致。乳酸脱氢酶的同工酶模式在不同甲状腺疾病之间无显著差异。