Pieper W A, Skeen M J
Adv Exp Med Biol. 1977;85B:42-55.
The magnitude of the ethanol withdrawal reaction was assessed in rhesus monkeys (Macaca mulatta) following 96 hours of either constant or systematically fluctuating blood ethanol concentrations (BEC) using both physiological tremor and scores on a behavioral checklist as dependent measures. Although specific BEC (50, 100, 200 or 300 mg/dl) were not reliably related to changes in mean frequency of tremor, this measure was a statistically significant curvilinear function of time as measured before and after zero BEC during the withdrawal period. Further, scores from the behavioral checklist demonstrated a dose-response relationship with respect to BEC. The data also suggest that systematically fluctuating BEC are associated with less severe withdrawal reactions when compared with appropriate data from the constant BEC condition.
在恒河猴（猕猴）中，通过使用生理震颤和行为检查表评分作为因变量，在血液乙醇浓度（BEC）持续96小时恒定或系统波动后，评估乙醇戒断反应的强度。尽管特定的BEC（50、100、200或300mg/dl）与震颤平均频率的变化没有可靠的相关性，但该指标是戒断期零BEC前后测量的时间的统计学显著曲线函数。此外，行为检查表的评分显示出与BEC的剂量反应关系。数据还表明，与恒定BEC条件下的适当数据相比，系统波动的BEC与较轻的戒断反应相关。
