Benbassat J, Slavin M, Zlotnick A
Br J Cancer. 1974 Feb;29(2):143-50. doi: 10.1038/bjc.1974.50.
Mouse myeloma cells (MPC-11) secreting gamma-2-b globulin were shown to proliferate into solid tumours after transplantation into the hamster cheek pouch. The implanted tumours continued to grow during the first 2 weeks; thereafter they diminished in size and disappeared completely a month after transplantation. The specific MPC-11 gammaglobulin could be detected in the serum of the hosts within 2 days after the transplantation and the changes in its concentration roughly correlated with the tumour size. The estimated half-life of the MPC-11 gammaglobulin in the circulation of the tumour-bearing hamsters was 4-6 days. Host resistance was demonstrated in tumour-bearing hamsters by their failure to develop tumours on second challenge with MPC-11 cells.
分泌γ-2-b球蛋白的小鼠骨髓瘤细胞（MPC-11）在移植到仓鼠颊囊后被证明会增殖形成实体瘤。植入的肿瘤在最初2周内持续生长；此后它们体积缩小，移植后一个月完全消失。移植后2天内即可在宿主血清中检测到特异性MPC-11γ球蛋白，其浓度变化大致与肿瘤大小相关。在荷瘤仓鼠的循环中，MPC-11γ球蛋白的估计半衰期为4-6天。荷瘤仓鼠在再次用MPC-11细胞攻击时未发生肿瘤，证明了宿主抗性。
