D'Silva Leah, Cheng Chloe, Barrow Joeva J
Division of Nutritional Sciences, Cornell University, Ithaca, NY, 14850, USA.
Department of Biological and Biomedical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, 14850, USA.
Trends Endocrinol Metab. 2025 Dec 2. doi: 10.1016/j.tem.2025.11.002.
Since the discovery that individuals with active brown adipose tissue (BAT) have lower prevalence of cardiometabolic diseases, it has been hypothesized that this depot can be targeted to improve human metabolic health. A major limitation with BAT, however, is that it is silenced under physiological temperatures, and the mechanisms that restrict its activation are not completely elucidated. To unlock the true potential of BAT, it is critical to understand the mechanisms governing its silencing. Herein, we provide an integrated review of the main regulatory factors that suppress thermogenic adipocytes, which we have termed 'thermogenic silencers', and present a series of perspectives to position thermogenic silencers as novel targets for the improvement of metabolic health in humans.
自从发现具有活跃棕色脂肪组织（BAT）的个体患心脏代谢疾病的患病率较低以来，人们就推测可以针对这个脂肪库来改善人类的代谢健康。然而，BAT的一个主要局限性在于，它在生理温度下会失活，且限制其激活的机制尚未完全阐明。为了释放BAT的真正潜力，了解其失活的调控机制至关重要。在此，我们对抑制产热脂肪细胞的主要调控因子进行了综合综述，我们将这些因子称为“产热沉默因子”，并提出了一系列观点，将产热沉默因子定位为改善人类代谢健康的新靶点。
