人类染色体中姐妹染色单体交换的定位
Localization of sister chromatid exchanges in human chromosomes.
作者信息
Latt S A
出版信息
Science. 1974 Jul 5;185(4145):74-6. doi: 10.1126/science.185.4145.74.
PMID:4134970
Abstract
The bromodeoxyuridine; sensitivity of 33258 Hoechst fluorescence allows microfluorometric analysis of sister chromatid exchanges in human metaphase chromosomes. The frequency of sister chromatid exchanges among chromosomes correlates with chromosome length. Exchanges appear to occur predominantly in interband regions, as defined by quinacrine fluorescence, or very near band-interband junctions. A few regions are involved unusually frequently.
摘要
溴脱氧尿苷；33258 Hoechst 荧光的敏感性使得能够对人类中期染色体中的姐妹染色单体交换进行微量荧光分析。染色体间姐妹染色单体交换的频率与染色体长度相关。交换似乎主要发生在由喹吖因荧光定义的带间区域，或非常靠近带 - 带间交界处。少数区域异常频繁地参与其中。
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