一种测量99锝标记的1-羟基-1,1-二膦酸乙烷在犬胫骨中蓄积情况的技术。

A technique for measuring the accumulation of 99 Tcm stannous-ethane-1-hydroxy-1, 1-diphosphonate in the canine tibia.

作者信息

Khan R A, Best J K, Lavender J P

出版信息

Br J Radiol. 1978 Jan;51(601):51-5. doi: 10.1259/0007-1285-51-601-51.

Abstract

An experimental technique is described to measure the accumulation of 99Tcm-stannous-ethane-1-hydroxy-1, 1-diphosphonate (99Tcm-EHDP) in the canine tibia. The method involves infusion at a constant rate of known amounts of 99Tcm-EHDP into the nutrient artery supplying the tibial bone. The accumulation of the diphosphonate in bone is measured by an external sodium iodide, Nal (T1), scintillation detector. Results are presented showing that for small amounts of 99Tcm-EHDP (0.004-0.300 mg per hour) the accumulation is a nearly linear function with time for 60 minutes, after which the uptake may become variable with either a plateau formation or considerable fluctuation of activity.

摘要

描述了一种实验技术，用于测量99锝-亚锡-乙烷-1-羟基-1,1-二膦酸盐（99锝-依替膦酸盐，99Tcm-EHDP）在犬胫骨中的蓄积情况。该方法包括以恒定速率将已知量的99Tcm-EHDP注入供应胫骨的滋养动脉。二膦酸盐在骨中的蓄积通过外部碘化钠Nal（Tl）闪烁探测器进行测量。给出的结果表明，对于少量的99Tcm-EHDP（每小时0.004 - 0.300毫克），在60分钟内蓄积是一个几乎随时间呈线性的函数，此后摄取量可能会变得不稳定，出现平台形成或活性有相当大的波动。