Abel F L
Circ Shock. 1977;4(4):345-58.
The effects of glucocorticoids on fluid uptake and myocardial performance was investigated in 14 dogs and two baboons. The animals were placed into stimulated hemorrhagic shock using a servocontrolled pump to maintain arterial pressure at desired levels. Ventricular function curves were generated by stepwise changes in afterload or by venous infusion and the resultant data were grouped by digital computer into similar preload, heart rate, and afterload groupings. Fluid uptake was monitored from the pump reservoir. Methylprednisolone was given intravenously, 30 mg/kg, approximately 3 hr after the postinfusion period. Fluid loss decreased and ventricular performance improved, as measured by maximal dp/dt, (maximal dp/dt)/developed pressure, and time to peak ventricular pressure. The improvements with steroid infusion were relatively small, however, and were not maintained for more than about 3 hr. Heart rate decreased markedly in response to the steroid, despite a general vasodilator response. The glucocorticoids appear to have mild beneficial effects on the myocardium and on capillary permeability in the presence of high circulating levels of catecholamines in the postinfusion phase of hemorrhagic shock.
在14只狗和2只狒狒身上研究了糖皮质激素对液体摄取和心肌性能的影响。使用伺服控制泵将动物置于模拟失血性休克状态，以将动脉血压维持在所需水平。通过逐步改变后负荷或静脉输注来生成心室功能曲线，并使用数字计算机将所得数据分组为相似的前负荷、心率和后负荷分组。从泵储液器监测液体摄取情况。在输注期后约3小时静脉给予甲泼尼龙，剂量为30mg/kg。液体丢失减少，心室性能改善，通过最大dp/dt、（最大dp/dt）/舒张末期压力和达到心室压力峰值的时间来衡量。然而，类固醇输注带来的改善相对较小，且持续时间不超过约3小时。尽管有普遍的血管舒张反应，但心率因类固醇而显著下降。在失血性休克输注期后，当循环中儿茶酚胺水平较高时，糖皮质激素似乎对心肌和毛细血管通透性有轻微的有益作用。
