Brown G A, Osebold W R, Ponseti I V
Clin Orthop Relat Res. 1977 Oct(128):228-42.
Sixteen patients with pseudarthrosis of the tibia and one of the radius were evaluated clinically, radiograpically, and microscopically and separated into 3 groups; 8 had neurofibromatosis clinically, 3 had fibrous dysplasia histologically, and 6 had no evidence of either neurofibromatosis or fibrous dysplasia. Prognosis and therapy were determined by correlated clinical, radiographic, and histological observations. Fracture before age 2 years carried a poor prognosis. Electron microscopy allowed neither differentiation among these fibrous lesions, nor any clue to their origin, nor did it support the concept of a neural or vascular derivation.
对16例胫骨假关节患者和1例桡骨假关节患者进行了临床、影像学和显微镜检查评估，并分为3组；8例临床上患有神经纤维瘤病，3例组织学上患有纤维发育不良，6例既无神经纤维瘤病也无纤维发育不良的证据。通过相关的临床、影像学和组织学观察来确定预后和治疗方法。2岁前骨折预后较差。电子显微镜检查既无法区分这些纤维性病变，也无法提供其起源的任何线索，也不支持神经源性或血管源性的概念。
