甲胎蛋白：肝癌进展或消退的指标，以及免疫治疗的靶点。
Alpha Fetoprotein: An index of progression or regression of hepatoma, and a target for immunotherapy.
作者信息
Parks L C, Baer A N, Pollack M, Williams G M
出版信息
Ann Surg. 1974 Oct;180(4):599-605. doi: 10.1097/00000658-197410000-00025.
Abstract
CLINICAL AND LABORATORY STUDIES OF AFP PRODUCING HEPATOMAS DEMONSTRATED THAT
- serum AFP levels correlated directly with tumor growth; 2) circulating AFP could be cleared by passive administration of an. excess of anti-AFP; and 3) highly specific anti-AFP functioned as a carrier to localize diagnostic and possibly therapeutic amounts of radioactivity in hepatoma tissue. These studies helped elucidate certain criteria which should be fulfilled before attempts to initiate passive humoral immunotherapy of cancer are undertaken.
摘要
对产生甲胎蛋白的肝癌进行的临床和实验室研究表明
1）血清甲胎蛋白水平与肿瘤生长直接相关；2）通过被动给予过量抗甲胎蛋白可清除循环中的甲胎蛋白；3）高特异性抗甲胎蛋白可作为载体，使诊断性及可能的治疗性放射性物质在肝癌组织中定位。这些研究有助于阐明在尝试启动癌症被动体液免疫治疗之前应满足的某些标准。
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Alpha Fetoprotein: An index of progression or regression of hepatoma, and a target for immunotherapy.甲胎蛋白：肝癌进展或消退的指标，以及免疫治疗的靶点。
Ann Surg. 1974 Oct;180(4):599-605. doi: 10.1097/00000658-197410000-00025.
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本文引用的文献
1
VASCULAR RELATIONSHIPS OF TUMOR AND HOST.
Prog Exp Tumor Res. 1964;4:57-97. doi: 10.1159/000385974.
2
Photoscan localization of GW-39 tumors in hamsters using radiolabeled anticarcinoembryonic antigen immunoglobulin G.
Cancer Res. 1974 Jan;34(1):1-9.
3
Localization of human GW-39 tumors in hamsters by radiolabeled heterospecific antibody to carcinoembryonic antigen.
Cancer Res. 1973 Nov;33(11):2977-82.
4
Production of embryonal serum alpha-globulin by hepatomas: review of experimental and clinical data.肝癌产生胚胎血清甲种球蛋白：实验与临床数据综述
Cancer Res. 1968 Jul;28(7):1344-50.
5
A method of trace iodination of proteins for immunologic studies.一种用于免疫学研究的蛋白质微量碘化方法。
Int Arch Allergy Appl Immunol. 1966;29(2):185-9. doi: 10.1159/000229699.
6
Localization of -fetoprotein in hepatoma tissues by immunofluorescence.
Cancer Res. 1972 Jan;32(1):162-6.
7
The occurrence of a serum fetal alpha-1 protein in developing mice and murine hepatomas and teratomas.血清胎儿α-1蛋白在发育中小鼠、鼠肝癌和畸胎瘤中的出现。
Cancer Res. 1971 Jul;31(7):930-6.
8
Isolation and characterization of a human fetal-alpha-globulin from the sera of fetuses and a hepatoma patient.从胎儿和一名肝癌患者的血清中分离并鉴定一种人胎儿α-球蛋白。
Cancer Res. 1970 Oct;30(10):2507-13.
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