Strayer D S, Cosenza H, Lee W M, Rowley D A, Köhler H
Science. 1974 Nov 15;186(4164):640-3. doi: 10.1126/science.186.4164.640.
Specific immunologic unresponsiveness is induced by injecting adult or neonatal mice with antibody against antigen-specific receptor (antireceptor antibody). Suppression in mice treated as adults lasts several weeks, and cells from these suppressed mice respond normally in culture. In contrast, unresponsiveness induced in neonatal mice is long-lasting; cells from these mice do not respond in culture and do not affect the response of normal cells. Evidently, antireceptor antibody reversibly blocks antigen receptors in adult animals, but induces unresponsiveness in neonatal mice by depleting the clone of receptor-bearing cells.
通过给成年或新生小鼠注射针对抗原特异性受体的抗体（抗受体抗体）可诱导特异性免疫无反应性。成年小鼠接受该处理后产生的抑制作用可持续数周，且这些受抑制小鼠的细胞在培养中反应正常。相比之下，新生小鼠诱导产生的无反应性是持久的；这些小鼠的细胞在培养中无反应，且不影响正常细胞的反应。显然，抗受体抗体在成年动物中可逆地阻断抗原受体，但通过消耗携带受体的细胞克隆在新生小鼠中诱导无反应性。
