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1
Restoration of immune competence in tolerant mice by parabiosis to normal mice.通过与正常小鼠联体共生来恢复耐受小鼠的免疫能力。
J Exp Med. 1974 Nov 1;140(5):1421-6. doi: 10.1084/jem.140.5.1421.
2
Specific suppression of the immune response by HGG tolerant spleen cells. I. Parameters affecting the level of suppression.HGG耐受脾细胞对免疫反应的特异性抑制。I. 影响抑制水平的参数。
J Immunol. 1976 Jun;116(6):1640-5.
3
Immunologic tolerance to HGG in mice. I. Suppression of the HGG response in normal mice with spleen cells or a spleen cell lysate from tolerant mice.小鼠对马血清球蛋白（HGG）的免疫耐受性。I. 用来自耐受小鼠的脾细胞或脾细胞裂解物抑制正常小鼠的HGG反应。
J Immunol. 1977 May;118(5):1880-5.
4
Antibody plaque-orming cells in mice immunized with human gamma globulin (HGG). II. Inhibition by mouse anti-HGG serum and human rheumatoid factor.用人γ球蛋白（HGG）免疫的小鼠中的抗体形成细胞。II. 小鼠抗HGG血清和人类风湿因子的抑制作用
J Immunol. 1971 Mar;106(3):792-8.
5
Comparison of the developmental kinetics of antibody- and immunoglobulin-forming cells in normal and tolerant mice.正常小鼠和耐受小鼠中抗体形成细胞与免疫球蛋白形成细胞发育动力学的比较。
J Immunol. 1978 Nov;121(5):2070-6.
6
Suppressor cells in tolerance to HGG: kinetics and cross-suppression in high dose tolerance--absence in low dose tolerance.对人γ球蛋白（HGG）耐受中的抑制细胞：高剂量耐受的动力学和交叉抑制——低剂量耐受中不存在
J Immunol. 1977 Jun;118(6):2125-9.
7
Induction of immunologic tolerance in nursing neonates by absorption of tolerogen from colostrum.通过从初乳中吸收耐受原诱导哺乳新生儿的免疫耐受。
J Immunol. 1976 May;116(5):1204-7.
8
Specific, transient suppression of the immune response by HGG tolerant spleen cells. II. Effector cells and target cells.经HGG耐受脾细胞对免疫反应进行特异性、短暂性抑制。II. 效应细胞和靶细胞。
J Immunol. 1976 Oct;117(4):1152-8.
9
Specific suppression of the immune response by a factor obtained from spleen cells of mice tolerant to human gamma-globulin.从小鼠脾脏细胞中获得的一种因子对免疫反应的特异性抑制，该小鼠对人γ球蛋白具有耐受性。
J Immunol. 1978 Jan;120(1):21-6.
10
Immunological tolerance: high-dose antigen-induced suppressor cells from tolerant animals inactivate antigen-presenting macrophages.免疫耐受：来自耐受动物的高剂量抗原诱导的抑制细胞使抗原呈递巨噬细胞失活。
Proc Natl Acad Sci U S A. 1979 May;76(5):2405-9. doi: 10.1073/pnas.76.5.2405.

引用本文的文献

1
Current perspectives on the cellular mechanisms of immunologic tolerance.免疫耐受细胞机制的当前观点
Clin Exp Immunol. 1980 Feb;39(2):257-62.
2
Cellular basis of persistent tolerance induced by an aggregate free heterologous immunoglobulin.无聚集物的异源免疫球蛋白诱导的持续性耐受的细胞基础
Immunology. 1977 Nov;33(5):635-41.
3
Induction and mode of action of suppressor cells generated against human gamma globulin. II. Effects of colchicine.针对人丙种球蛋白产生的抑制细胞的诱导及作用方式。II. 秋水仙碱的作用
J Exp Med. 1979 May 1;149(5):1168-82. doi: 10.1084/jem.149.5.1168.
4
Tolerance induction during ontogeny. I. Presence of active suppression in mice rendered tolerant to human gamma-globulin in utero correlates with the breakdown of the tolerant state.个体发育过程中的耐受性诱导。I. 子宫内对人γ球蛋白产生耐受性的小鼠中存在的主动抑制与耐受状态的破坏相关。
J Exp Med. 1979 May 1;149(5):1134-51. doi: 10.1084/jem.149.5.1134.
5
Induction and mode of action of suppressor cells generated against human gamma globulin. I. An immunologic unresponsive state devoid of demonstrable suppressor cells.针对人丙种球蛋白产生的抑制细胞的诱导及作用方式。I. 一种缺乏可证实的抑制细胞的免疫无反应状态。
J Exp Med. 1978 Sep 1;148(3):625-38. doi: 10.1084/jem.148.3.625.

本文引用的文献

1
Tolerance of F1 hybrid skin homografts in the parent strain induced by parabiosis.联体生活诱导亲本品系对F1杂种皮肤同种移植物的耐受性。
Proc Soc Exp Biol Med. 1960 Feb;103:266-9. doi: 10.3181/00379727-103-25483.
2
Genetic factors in parabiosis.联体生活中的遗传因素。
J Natl Cancer Inst. 1959 Dec;23:1193-213.
3
Binding of 125I-BSA to lymphoid cells of tolerant mice.125I标记的牛血清白蛋白与耐受小鼠淋巴细胞的结合
Int Arch Allergy Appl Immunol. 1969;36(1):112-3. doi: 10.1159/000230728.
4
Glutaraldehyde, cyanuric chloride and tetrazotized O-dianisidine as coupling reagents in the passive hemagglutination test.戊二醛、三聚氯氰和四氮唑化邻联茴香胺作为被动血凝试验中的偶联试剂。
Immunochemistry. 1969 Jan;6(1):67-76. doi: 10.1016/0019-2791(69)90179-7.
5
The abrogation of sheep erythrocyte tolerance in rats by means of the transfer of allogeneic lymphocytes.通过同种异体淋巴细胞转移消除大鼠对绵羊红细胞的耐受性。
J Exp Med. 1970 Nov;132(5):916-25. doi: 10.1084/jem.132.5.916.
6
Attempts to demonstrate an in vivo role for serum blocking factors in tolerant mice.尝试证明血清阻断因子在耐受小鼠体内的作用。
Transplantation. 1972 Sep;14(3):382-7. doi: 10.1097/00007890-197209000-00016.
7
Immunosuppressive effect of serum from CBA mice made tolerant by the subernatant from ultracentrifuged bovine gamma globulin.经超速离心牛γ球蛋白上清液诱导产生耐受的CBA小鼠血清的免疫抑制作用
J Immunol. 1970 Aug;105(2):426-30.
8
Studies on the induction of immunologic unresponsiveness. 3. Antigen form and mouse strain variation.免疫无反应性诱导的研究。3. 抗原形式与小鼠品系差异。
J Immunol. 1969 Feb;102(2):389-96.
9
A modification of the hemolytic plaque assay for use with protein antigens.一种用于蛋白质抗原的溶血空斑试验的改良方法。
J Immunol. 1968 Jan;100(1):133-7.
10
Termination of tolerance to human gamma globulin in mice by antigen and bacterial lipopolysaccharide (endotoxin).通过抗原和细菌脂多糖（内毒素）终止小鼠对人γ球蛋白的耐受性。
J Exp Med. 1973 Mar 1;137(3):740-50. doi: 10.1084/jem.137.3.740.

通过与正常小鼠联体共生来恢复耐受小鼠的免疫能力。

Restoration of immune competence in tolerant mice by parabiosis to normal mice.

作者信息

Zolla S, Naor D

出版信息

J Exp Med. 1974 Nov 1;140(5):1421-6. doi: 10.1084/jem.140.5.1421.

DOI:10.1084/jem.140.5.1421
PMID:4138703
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2139713/
Abstract

These studies demonstrate that mice tolerant to human gamma globulin (HGG) regain their ability to make antibody to HGG after parabiosis to normal mice. This can be demonstrated by enumeration of PFC in the spleens of both the normal and tolerant partners. Hemagglutinin titers of normal-tolerant parabionts, however, are exceptionally low; serum antibody appears to be neutralized by circulating HGG present originally in the serum of the tolerant partner. These data support the hypothesis that tolerance to HGG in mice is a "defective" state due to the absence of cells capable of responding to this antigen.

摘要

这些研究表明，对人丙种球蛋白（HGG）产生耐受的小鼠在与正常小鼠联体共生后，恢复了产生抗HGG抗体的能力。这可以通过对正常和耐受联体伙伴脾脏中的空斑形成细胞（PFC）进行计数来证明。然而，正常-耐受联体共生体的血凝素滴度极低；血清抗体似乎被最初存在于耐受伙伴血清中的循环HGG中和。这些数据支持了这样一种假说，即小鼠对HGG的耐受是一种“缺陷”状态，这是由于缺乏能够对该抗原作出反应的细胞所致。