个体发育过程中的耐受性诱导。I. 子宫内对人γ球蛋白产生耐受性的小鼠中存在的主动抑制与耐受状态的破坏相关。
Tolerance induction during ontogeny. I. Presence of active suppression in mice rendered tolerant to human gamma-globulin in utero correlates with the breakdown of the tolerant state.
作者信息
Waters C A, Pilarski L M, Wegmann T G, Diener E
出版信息
J Exp Med. 1979 May 1;149(5):1134-51. doi: 10.1084/jem.149.5.1134.
Abstract
A specific state of T- and B-cell tolerance to human gamma-globulin (HGG) was induced in utero by intravenous administration of the deaggregated antigen to pregnant BALB/cCr mice. Tolerance persisted in the offspring until the 12th-wk of age and then began to gradually disappear. Suppressor cells could only be found when responsiveness to HGG ultimately appeared in the in utero-treated animals but not when they were completely unresponsives. In contrast, HGG-specific suppressors found in animals made unresponsive to HGG as adults appear to be associated with either the establishment and/or maintenance of the unresponsive state. To the extent that these experiments are consistent with natural self-tolerance to a serum protein, we conclude that active suppression is not a prerequisite from maintenance of unresponsiveness to self.
摘要
通过向怀孕的BALB/cCr小鼠静脉注射去聚合抗原，在子宫内诱导了T细胞和B细胞对人丙种球蛋白（HGG）的特异性耐受状态。这种耐受在后代中持续到12周龄，然后开始逐渐消失。仅在子宫内处理的动物最终对HGG出现反应性时才能发现抑制细胞，而在它们完全无反应时则未发现。相比之下，在成年后对HGG无反应的动物中发现的HGG特异性抑制细胞似乎与无反应状态的建立和/或维持有关。就这些实验与对血清蛋白的天然自身耐受一致而言，我们得出结论，主动抑制不是维持对自身无反应性的先决条件。
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