Halsey J F, Benjamin D C
J Immunol. 1976 May;116(5):1204-7.
Deaggregatedhuman gamma-globulin (DHGG) injected into female mice within 24 hr after delivery of a litter enters the colostrum and is absorbed intact through the intestine by nursing neonates. This absorbed HGG was present in the neonatal circulation at concentrations of 0.3 to 0.6 mg/ml of serum under the experimental conditions used. This absorption of HGG by the nursing neonate resulted in a complete, specific, tolerant state to HGG. This tolerant state was stable upon adoptive cell transfer and could not be abrogated by transfer of normal syngeneic spleen cells.
在一窝幼崽出生后24小时内注射到雌性小鼠体内的解聚人γ-球蛋白（DHGG）进入初乳，并被哺乳的新生小鼠完整地通过肠道吸收。在所使用的实验条件下，这种吸收的HGG在新生小鼠的循环系统中的血清浓度为0.3至0.6毫克/毫升。哺乳的新生小鼠对HGG的这种吸收导致了对HGG完全、特异性的耐受状态。这种耐受状态在过继细胞转移后是稳定的，并且不能通过转移正常的同基因脾细胞而被消除。
