大肠杆菌中两种多糖K抗原K10和K54抗原决定簇的基因定位
Genetic mapping of the antigenic determinants of two polysaccharide K antigens, K10 and K54, in Escherichia coli.
作者信息
Orskov I, Nyman K
出版信息
J Bacteriol. 1974 Oct;120(1):43-51. doi: 10.1128/jb.120.1.43-51.1974.
Abstract
The genes controlling synthesis of the Escherichia coli acidic polysaccharide capsular antigens K10 and K54 were transferred by conjugation to E. coli strains of other serotypes. The genes concerned with these K antigen determinants showed genetic linkage with the serA locus. We propose to name the K antigen-controlling gene kpsA. The genetic determinants of the two K antigens could also be transferred to enteropathogenic serotypes, even though such strains have never been found in nature with special acidic polysaccharide K antigens. A noncapsulated derivative, K(-), of the K10 strain can transfer the genetic determinant of the K antigen, demonstrating the probable existence of another chromosomal locus involved in the production of such acidic polysaccharide K antigens.
摘要
控制大肠杆菌酸性多糖荚膜抗原K10和K54合成的基因通过接合转移到其他血清型的大肠杆菌菌株中。与这些K抗原决定簇相关的基因与serA位点显示出遗传连锁。我们提议将控制K抗原的基因命名为kpsA。这两种K抗原的遗传决定簇也可以转移到肠道致病性血清型中，尽管在自然界中从未发现过带有特殊酸性多糖K抗原的此类菌株。K10菌株的无荚膜衍生物K(-)可以转移K抗原的遗传决定簇，这表明可能存在另一个参与此类酸性多糖K抗原产生的染色体位点。
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Genetic mapping of the antigenic determinants of two polysaccharide K antigens, K10 and K54, in Escherichia coli.大肠杆菌中两种多糖K抗原K10和K54抗原决定簇的基因定位
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