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编码尿路致病性大肠杆菌中P菌毛黏附素的基因的染色体图谱位置。

Chromosomal map position of genes encoding P adhesins in uropathogenic Escherichia coli.

作者信息

Hull R, Bieler S, Falkow S, Hull S

出版信息

Infect Immun. 1986 Feb;51(2):693-5. doi: 10.1128/iai.51.2.693-695.1986.

DOI:10.1128/iai.51.2.693-695.1986
PMID:2867976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC262411/
Abstract

Escherichia coli isolates from upper urinary tract infections frequently express adherence to human uroepithelium and D-mannose-resistant hemagglutination of human erythrocytes. Such adherence is usually associated with P pili encoded by the pap operon(s). In this paper, we report approximate chromosomal map positions for two copies of the pap operon. Only one copy expressed an adhesin capable of D-mannose-resistant hemagglutination, although both expressed P-related antigen.

摘要

从上行性尿路感染中分离出的大肠杆菌菌株常常表现出对人尿道上皮的黏附以及对人红细胞的D-甘露糖抗性血凝作用。这种黏附通常与由pap操纵子编码的P菌毛有关。在本文中，我们报告了pap操纵子两个拷贝的大致染色体图谱位置。尽管两个拷贝都表达与P相关的抗原，但只有一个拷贝表达能够产生D-甘露糖抗性血凝作用的黏附素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bff/262411/d3ca3a8b984d/iai00107-0330-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bff/262411/d3ca3a8b984d/iai00107-0330-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bff/262411/d3ca3a8b984d/iai00107-0330-a.jpg

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Infect Immun. 1986 Feb;51(2):693-5. doi: 10.1128/iai.51.2.693-695.1986.
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本文引用的文献

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Inhibition of experimental ascending urinary tract infection by an epithelial cell-surface receptor analogue.上皮细胞表面受体类似物对实验性上行性尿路感染的抑制作用
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Genetics of hemolysin of Escherichia coli.大肠杆菌溶血素的遗传学
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Reciprocal exchange of minor components of type 1 and F1C fimbriae results in hybrid organelles with changed receptor specificities.1型菌毛和F1C菌毛的次要成分相互交换，产生了具有改变的受体特异性的杂交细胞器。
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The export systems of type 1 and F1C fimbriae are interchangeable but work in parental pairs.1型菌毛和F1C菌毛的输出系统可互换，但以亲本对的形式发挥作用。
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Clonal relationships among bloodstream isolates of Escherichia coli.大肠杆菌血流分离株之间的克隆关系。
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Functional and structural homology among regulatory cistrons of pili-adhesin determinants in Escherichia coli.大肠杆菌菌毛粘附素决定簇调控顺反子间的功能和结构同源性
Mol Gen Genet. 1988 Jun;212(3):412-7. doi: 10.1007/BF00330844.
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A block of urovirulence genes encoding multiple fimbriae and hemolysin in Escherichia coli O4:K12:H-.大肠杆菌O4:K12:H-中一组编码多种菌毛和溶血素的尿路致病基因。
Infect Immun. 1988 Feb;56(2):513-7. doi: 10.1128/iai.56.2.513-517.1988.
9
Aerobactin and other virulence factor genes among strains of Escherichia coli causing urosepsis: association with patient characteristics.引起泌尿道感染败血症的大肠杆菌菌株中的气杆菌素及其他致病因子基因：与患者特征的关联
Infect Immun. 1988 Feb;56(2):405-12. doi: 10.1128/iai.56.2.405-412.1988.
10
Molecular cloning of the Escherichia coli O75X adhesin.大肠杆菌O75X黏附素的分子克隆
Infect Immun. 1987 Dec;55(12):3168-73. doi: 10.1128/iai.55.12.3168-3173.1987.
J Infect Dis. 1981 Mar;143(3):325-45. doi: 10.1093/infdis/143.3.325.
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Linkage map of Escherichia coli K-12, edition 7.大肠杆菌K-12连锁图谱，第7版。
Microbiol Rev. 1983 Jun;47(2):180-230. doi: 10.1128/mr.47.2.180-230.1983.
5
Gene clusters governing the production of hemolysin and mannose-resistant hemagglutination are closely linked in Escherichia coli serotype O4 and O6 isolates from urinary tract infections.在从尿路感染患者分离出的大肠杆菌O4和O6血清型菌株中，控制溶血素产生和甘露糖抗性血凝反应的基因簇紧密相连。
Infect Immun. 1984 Jan;43(1):353-8. doi: 10.1128/iai.43.1.353-358.1984.
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Influence of adhesins on the interaction of Escherichia coli with human phagocytes.黏附素对大肠杆菌与人吞噬细胞相互作用的影响。
Infect Immun. 1984 Jun;44(3):672-80. doi: 10.1128/iai.44.3.672-680.1984.
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Frequency of gene sequences necessary for pyelonephritis-associated pili expression among isolates of Enterobacteriaceae from human extraintestinal infections.人类肠外感染的肠杆菌科分离株中与肾盂肾炎相关菌毛表达所需基因序列的频率。
Infect Immun. 1984 Mar;43(3):1064-7. doi: 10.1128/iai.43.3.1064-1067.1984.
8
Proteinaceous bacterial adhesins and their receptors.蛋白质类细菌黏附素及其受体。
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Contribution of adhesion to bacterial persistence in the mouse urinary tract.黏附对小鼠泌尿道中细菌持续性的作用。
Infect Immun. 1983 Apr;40(1):265-72. doi: 10.1128/iai.40.1.265-272.1983.
10
F7 and type 1-like fimbriae from three Escherichia coli strains isolated from urinary tract infections: protein chemical and immunological aspects.从尿路感染分离出的三株大肠杆菌的F7和1型菌毛：蛋白质化学和免疫学方面
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