Pham Q T, Mire B
J Occup Med. 1978 Jan;20(1):33-8. doi: 10.1097/00043764-197801000-00008.
Workers at two continental European enzyme detergent plants were examined to determine respiratory symptomatology, pulmonary function abnormalities and skin reactivity to four enzymes through use of a standardized questionnaire, flow-volume curves and provocative acetylcholine, single breath carbon monoxide, and prick tests. In both plants, the frequency of bronchitis was similar but the frequency of asthmatic or rhinopharyngitic symptoms was different. Symptomatology was more frequent in female detergent workers than among the clerical staff but no difference among men in different jobs was noted. Very few spirometric abnormalities were observed but bronchial hyperactivity was more frequent in packaging and warehouse workers. No correlation between DLco/AV and of work or skin reactivity was found. Skin reactivity (about 10% in both plants) and duration of employment were not related to symptomatology nor functional abnormalities.
对两家欧洲大陆酶洗涤剂工厂的工人进行了检查，通过使用标准化问卷、流量-容积曲线以及乙酰甲胆碱激发试验、单次呼吸一氧化碳试验和点刺试验，来确定呼吸症状、肺功能异常以及对四种酶的皮肤反应性。在两家工厂中，支气管炎的发生率相似，但哮喘或鼻咽炎症状的发生率不同。女性洗涤剂工人的症状比文职人员更常见，但不同工作的男性之间未发现差异。观察到的肺功能异常很少，但包装和仓库工人的支气管高反应性更常见。未发现一氧化碳弥散量/肺泡容积与工作或皮肤反应性之间存在相关性。皮肤反应性（两家工厂均约为10%）和工作时长与症状或功能异常均无关。
