Synthesis and analgetic activity of 1,2,3,4,5,6-hexahydro-1,6-methano-3-benzozocines.
作者信息
Mazzocchi P H, Harrison A M
出版信息
J Med Chem. 1978 Feb;21(2):238-40. doi: 10.1021/jm00200a021.
PMID:413922
Abstract
1,2,3,4,5,6-Hexahydro-1,6-methano-3-benzazocine (1) has been synthesized via a four-step sequence from benzo-norbornadiene. This compound and its N-methyl derivative are more active than codeine in the mouse hot-plate antinociceptive assay and will not suppor morphine dependence in Rhesus monkeys.
摘要
相似文献
1
Synthesis and analgetic activity of 1,2,3,4,5,6-hexahydro-1,6-methano-3-benzozocines.
J Med Chem. 1978 Feb;21(2):238-40. doi: 10.1021/jm00200a021.
2
9-hydroxy-1,2,3,4,5,6-hexahydro-1,5-methano-3-benzazocine derivatives as analgesics.9-羟基-1,2,3,4,5,6-六氢-1,5-亚甲基-3-苯并氮杂卓衍生物作为镇痛药。
J Med Chem. 1977 Feb;20(2):310-2. doi: 10.1021/jm00212a027.
3
1,2,3,4,5,6-hexahydro-6-phenyl-2,6-methano-3-benzazocines. I. The 3-carboxamido-8-hydroxy derivative as an orally effective analgetic.1,2,3,4,5,6-六氢-6-苯基-2,6-亚甲基-3-苯并氮杂卓。I. 3-羧酰胺基-8-羟基衍生物作为口服有效的镇痛药。
J Med Chem. 1969 Sep;12(5):845-7. doi: 10.1021/jm00305a029.
4
Synthesis and analgetic activity of 1,5-methano-3-methyl-1,2,3,4,5,6-hexahydro-3-benzazocines.
J Med Chem. 1971 Oct;14(10):1011-3. doi: 10.1021/jm00292a041.
5
Studies on the syntheses of analgesics. VI. Synthesis of 1,2,3,4,5,6-hexahydro-1,5-methano-3-benzazocine derivatives.
Chem Pharm Bull (Tokyo). 1975 Sep;23(9):1932-7. doi: 10.1248/cpb.23.1932.
6
Analgetic activity and in vitro binding constants of some N-alkyl-3-benzazocines.
J Med Chem. 1975 Oct;18(10):1036-8. doi: 10.1021/jm00244a020.
7
Synthesis and pharmacology of 5-noralkyl-9beta-methyl-6,7-benzomorphans and stereochemistry of some intermediates.5-去甲烷基-9β-甲基-6,7-苯并吗啡烷的合成与药理学及某些中间体的立体化学
J Med Chem. 1975 Aug;18(8):787-91. doi: 10.1021/jm00242a005.
8
[Synthesis of various N-acyl derivatives of 1,2,3,4,5,6-hexahydro-6-methyl- and 6,11-dimethyl-2,6-methano-3-benzazocine].
Acta Pol Pharm. 1987;44(5):411-4.
9
Synthesis and pharmacological properties of 1,2,3,4,5,6-hexahydro-1,6-methano-2-benzazocines.1,2,3,4,5,6-六氢-1,6-亚甲基-2-苯并氮杂卓的合成及药理性质
J Med Chem. 1981 Apr;24(4):457-62. doi: 10.1021/jm00136a016.
10
Preparation and analgesic activity of (-)-11 alpha-substituted 1,2,3,4,5,6-hexahydro-6 alpha,7-(methyleneoxy)-2,6-methano-3-benzazocines.
J Med Chem. 1986 Oct;29(10):1929-33. doi: 10.1021/jm00160a022.
Zotero 插件