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Synthesis and analgetic activity of 1,2,3,4,5,6-hexahydro-1,6-methano-3-benzozocines.

作者信息

Mazzocchi P H, Harrison A M

出版信息

J Med Chem. 1978 Feb;21(2):238-40. doi: 10.1021/jm00200a021.

DOI:10.1021/jm00200a021
PMID:413922
Abstract

1,2,3,4,5,6-Hexahydro-1,6-methano-3-benzazocine (1) has been synthesized via a four-step sequence from benzo-norbornadiene. This compound and its N-methyl derivative are more active than codeine in the mouse hot-plate antinociceptive assay and will not suppor morphine dependence in Rhesus monkeys.

摘要

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Synthesis and analgetic activity of 1,2,3,4,5,6-hexahydro-1,6-methano-3-benzozocines.
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