基础血清免疫球蛋白E水平的遗传控制及其对特异性反应素敏感性的影响。
Genetic control of basal serum immunoglobulin E level and its effect on specific reaginic sensitivity.
作者信息
Marsh D G, Bias W B, Ishizaka K
出版信息
Proc Natl Acad Sci U S A. 1974 Sep;71(9):3588-92. doi: 10.1073/pnas.71.9.3588.
Abstract
Studies of the distribution of total serum immunoglobulin E levels in nonallergic and allergic populations defined a cut-off point between low and high immunoglobulin E at 95 U/ml, based on Mendelian recessive inheritance of high immunoglobulin E level. Subsequent investigations of the distribution of total serum immunoglobulin E levels in 28 allergic families confirmed the recessive hypothesis. The results of quantitative skin tests in eight families, performed with between five and eight highly purified grass and ragweed pollen allergens per family, demonstrate that the immunoglobulin E-regulating gene exerts a profound effect on specific immunoglobulin E-mediated sensitivity, often masking the effect of HL-A associated immune response genes.
摘要
对非过敏人群和过敏人群血清总免疫球蛋白E水平分布的研究，基于高免疫球蛋白E水平的孟德尔隐性遗传，确定了低免疫球蛋白E和高免疫球蛋白E之间的分界点为95 U/ml。随后对28个过敏家庭血清总免疫球蛋白E水平分布的调查证实了隐性假说。在8个家庭中进行的定量皮肤试验结果显示，每个家庭使用5至8种高度纯化的草和豚草花粉过敏原，表明免疫球蛋白E调节基因对特异性免疫球蛋白E介导的敏感性有深远影响，常常掩盖了HL - A相关免疫反应基因的作用。
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Genetic control of basal serum immunoglobulin E level and its effect on specific reaginic sensitivity.基础血清免疫球蛋白E水平的遗传控制及其对特异性反应素敏感性的影响。
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