补充维生素C治疗压疮

Ascorbic acid supplementation in the treatment of pressure-sores.

作者信息

Taylor T V, Rimmer S, Day B, Butcher J, Dymock I W

出版信息

Lancet. 1974 Sep 7;2(7880):544-6. doi: 10.1016/s0140-6736(74)91874-1.

Abstract

In a prospective double-blind controlled trial the effect of large doses of ascorbic acid on the healing of pressure-sores has been assessed. 20 surgical patients were studied, the pressure areas being assessed by serial photography and ulcer tracings. The mean ascorbic-acid levels in treated and non-treated groups one month after the start of treatment were 65.6 and 25.8 mug per 10-8 white blood-cells. In the group treated with ascorbic acid there was a mean reduction in pressure-sore area of 84% after one month compared with 42.7% in the placebo group. These findings are statistically significant (P less than 0.005) and suggest that ascorbic acid may accelerate the healing of pressure-sores.

摘要

在一项前瞻性双盲对照试验中，评估了大剂量抗坏血酸对压疮愈合的影响。研究了20名外科手术患者，通过系列摄影和溃疡描记对受压部位进行评估。治疗开始后1个月，治疗组和未治疗组每10⁸个白细胞中抗坏血酸的平均水平分别为65.6微克和25.8微克。与安慰剂组42.7%的压疮面积平均减少相比，抗坏血酸治疗组在1个月后压疮面积平均减少了84%。这些结果具有统计学意义（P小于0.005），表明抗坏血酸可能会加速压疮的愈合。