Hiemstra S, Ziegler E, Steichele C
MMW Munch Med Wochenschr. 1977 Dec 9;119(49):1599-602.
More recent investigations on the duration of effect and plasma half-life of propranolol suggest a simplification of dosage for the beta-blocker in the treatment of hypertension. A field trial with Dociton 80 twice daily as initial therapy was carried out in over 2000 patients with essential hypertension with relatively few side effects and confirmed the distinctly longer-persisting effect of the beta-blocker on longterm application. Including the marginal values, the response rate in this collective was relatively high at 73%.
最近关于普萘洛尔作用持续时间和血浆半衰期的研究表明,在高血压治疗中可简化β受体阻滞剂的用药剂量。对2000多名原发性高血压患者进行了一项以每日两次服用80毫克多喜顿作为初始治疗的现场试验,副作用相对较少,并证实了β受体阻滞剂长期应用时具有明显更长的持续作用。包括边缘值在内,该组的有效率相对较高,为73%。