患病新西兰黑鼠血清中针对同基因成纤维细胞的抗体。
An antibody to isogeneic fibroblasts in the serum of diseased NZB mice.
作者信息
Liburd E, Russell A S, Dossetor J B
出版信息
Clin Exp Immunol. 1974 Apr;16(4):637-41.
Abstract
We have described a new autoantibody present in the serum of diseased NZB mice reactive with autochthonous and syngeneic fibroblasts. Allogeneic cells are not affected. This antibody can be specifically absorbed both by fibroblasts and lymphocytes from NZB but not from control mice. The antibody cannot act as a blocking factor to impair the cell-mediated killing of isogeneic fibroblasts by lymphocytes from diseased NZB mice. This suggests that the precise antigenic specificities of the cell-mediated and antibody responses are different.
摘要
我们已经描述了一种存在于患病新西兰黑鼠血清中的新型自身抗体，它可与自体和同基因成纤维细胞发生反应。异基因细胞不受影响。这种抗体可被来自新西兰黑鼠而非对照小鼠的成纤维细胞和淋巴细胞特异性吸收。该抗体不能作为一种阻断因子来削弱患病新西兰黑鼠淋巴细胞对同基因成纤维细胞的细胞介导杀伤作用。这表明细胞介导反应和抗体反应的精确抗原特异性是不同的。
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