Hijmans W, Radema H, van Es L, Feltkamp T E, van Loghem J J, Schaap O L
Clin Exp Immunol. 1969 Feb;4(2):227-39.
In about a quarter of New Zealand Black mice (NZB mice), aged 4 months or older, cryoglobulins were found, sometimes in large amounts. The frequency was somewhat higher in females than in males. The presence of cryoglobulins was rarely observed in control mice and in these groups the cryocrit always remained low. The majority of the cryoglobulins in NZB mice were macroglobulins with a relatively positive charge. Attempts to elucidate their significance have remained unsuccessful so far.
在约四分之一的4个月及以上的新西兰黑鼠(NZB小鼠)中发现了冷球蛋白,有时含量还很高。雌性的出现频率略高于雄性。在对照小鼠中很少观察到冷球蛋白的存在,且在这些组中冷沉淀比容始终较低。NZB小鼠中的大多数冷球蛋白是带相对正电荷的巨球蛋白。迄今为止,阐明它们意义的尝试仍未成功。