在严重缺乏T细胞的大鼠中对实验性变应性脑脊髓炎的抑制作用
Inhibition of experimental allergic encephalomyelitis in rats severely depleted of T cells.
作者信息
Gonatas N K, Howard J C
出版信息
Science. 1974 Nov 29;186(4166):839-41. doi: 10.1126/science.186.4166.839.
Lewis rats depleted of thymus-derived cells (B rats) failed to develop either experimental allergic encephalomyelitis or antibody against myelin basic protein. Lewis B rats reconstituted with 690 x 10(6) thymocytes developed experimental allergic encephalomyelitis and levels of antibody against myelin basic protein comparable to those of controls. The Lewis B rat model should be useful in the analysis of the role of thymus-derived cell populations and antibody in the induction of experimental allergic encephalomyelitis.
缺乏胸腺来源细胞的刘易斯大鼠（B大鼠）既未发生实验性变态反应性脑脊髓炎，也未产生抗髓鞘碱性蛋白的抗体。用690×10⁶个胸腺细胞重建的刘易斯B大鼠发生了实验性变态反应性脑脊髓炎，且抗髓鞘碱性蛋白的抗体水平与对照组相当。刘易斯B大鼠模型在分析胸腺来源细胞群体和抗体在实验性变态反应性脑脊髓炎诱导中的作用方面应具有实用性。
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