Ackermann H P, Ulrich J, Heitz P U
Acta Neuropathol. 1981;54(2):149-52. doi: 10.1007/BF00689408.
Classical acute allergic encephalomyelitis (EAE) was provoked in Lewis rats with bovine spinal cord (BWM) in complete Freund's adjuvant (CFA). An efficient immunohistologic technique (peroxidase-antiperoxidase (PAP) was used to trace exsudates of fibrinogen and immunoglobulin as well as their coexistence with cellular infiltrates and clinical signs. Exsudation was restricted to the vessels exhibiting cellular infiltrates. The findings do not lend support to the assumption that exsudation of circulating factors is the initial local event in EAE. It also remains open, whether the exsudation of fibrinogen and gamma globulin are responsible for the clinical symptoms.
用牛脊髓（BWM）加完全弗氏佐剂（CFA）在Lewis大鼠中诱发典型的急性变应性脑脊髓炎（EAE）。采用一种有效的免疫组织学技术（过氧化物酶-抗过氧化物酶法，PAP）来追踪纤维蛋白原和免疫球蛋白的渗出物，以及它们与细胞浸润和临床症状的共存情况。渗出仅限于出现细胞浸润的血管。这些发现不支持循环因子渗出是EAE初始局部事件的假设。纤维蛋白原和γ球蛋白的渗出是否导致临床症状也尚无定论。
