Greenberg L J, Chopky R L, Noreen H, Gray E D, Yunis E J, Ferrara G B
Vox Sang. 1978;34(3):136-42. doi: 10.1111/j.1423-0410.1978.tb02455.x.
Sera obtained from planned immunizations between unrelated donors and recipients, identical or compatible at HLA-A and B, were assessed for their capacity to alter the in vitro response of a test panel of lymphocytes to PHA and a purified streptococcal antigen (PAS). In the case of PHA, no serum effects were apparent. The response to PAS, however, significantly inhibited by two sera. When tested for their complement-dependent cytotoxicity on enriched populations of T and B lymphocytes, none of the sera manifested cytotoxicity against T cells nor did serological inhibition correlate with the capacity to lyze B cells. The data suggest that inhibition of the PSA response is mediated by blocking antibodies specific for a subset of lymphocytes, possibly T cells. While the precise mechanism governing the response to PSA is not known, the data are compatible with the idea that an HLA-linked Ir gene, expressed on a subset of T lymphocytes, controls immune responsiveness to PSA.
从无关供体和受体之间的计划免疫中获得的血清，在HLA - A和B位点相同或相容，评估其改变一组测试淋巴细胞对植物血凝素（PHA）和纯化链球菌抗原（PAS）的体外反应的能力。对于PHA，未观察到明显的血清效应。然而，对PAS的反应被两种血清显著抑制。当测试它们对富集的T和B淋巴细胞群体的补体依赖性细胞毒性时，没有一种血清表现出对T细胞的细胞毒性，血清学抑制也与裂解B细胞的能力无关。数据表明，对PAS反应的抑制是由针对淋巴细胞亚群（可能是T细胞）的阻断抗体介导的。虽然控制对PAS反应的精确机制尚不清楚，但这些数据与以下观点一致，即在T淋巴细胞亚群上表达的HLA连锁免疫反应基因控制对PAS的免疫反应性。
