Itoh H, Tokunaga S, Asamoto H, Furuta M, Funamoto Y, Kitaichi M, Torizuka K
AJR Am J Roentgenol. 1978 Feb;130(2):223-31. doi: 10.2214/ajr.130.2.223.
A radiologic and pathologic correlation has been made of small lung nodules. At necropsy 100 excised lungs were fixed and slices from them radiographed. The radiographs were used to select individual nodules for histologic study. Nodules in bronchopneumonia, acinonodose tuberculosis, chronic bronchiolitis, and simple pneumoconiosis due to ferric dust were shown to be located around inflamed terminal or respiratory bronchioles. Intraacinar infiltration was usually diffuse, but when nodules were seen, they occurred in peripheral airspaces with no relation to bronchioles. Hematogenous metastases showed distinctly marginated nodules, some truly intraacinar. Although each type of nodule can appear as an "acinar" or "subacinar" image on chest radiographs, this radiologic-pathologic study shows that they differ significantly in their relation to the airway structures.
已对肺小结节进行了放射学与病理学的相关性研究。尸检时，对100个切除的肺进行固定，并对其切片进行放射照相。利用这些射线照片挑选出单个结节进行组织学研究。结果显示，支气管肺炎、腺泡结节性结核、慢性细支气管炎以及铁尘所致单纯尘肺中的结节位于炎症终末细支气管或呼吸性细支气管周围。腺泡内浸润通常为弥漫性，但出现结节时，它们发生于外周气腔，与细支气管无关。血行转移表现为边界清晰的结节，有些确实位于腺泡内。尽管每种类型的结节在胸部射线照片上都可表现为“腺泡”或“腺泡下”影像，但这项放射学 - 病理学研究表明，它们与气道结构的关系存在显著差异。
