氧烯洛尔长期治疗对家兔和豚鼠细胞内电位及心脏功能其他特征的影响。
The effect of prolonged treatment with oxyfedrine on intracellular potentials and on other features of cardiac function in rabbits and guinea-pigs.
作者信息
Polster P, Vaughan Williams E M
出版信息
Br J Pharmacol. 1973 Feb;47(2):187-95. doi: 10.1111/j.1476-5381.1973.tb08316.x.
Abstract
- Previous work in acute experiments has shown that the main pharmacological action of oxyfedrine is stimulation of beta-adrenoceptors, yet there have been clinical reports that the drug is beneficial in the treatment of angina pectoris.2. In the present experiments rabbits and guinea-pigs were treated for several weeks with daily i.p. injections of oxyfedrine.3. A daily dosage of 15 mg/kg oxyfedrine had no effect on growth rate for 4 weeks, but thereafter the growth rate of treated animals fell below that of controls.4. The heart weights of the treated animals, expressed as a percentage of body weight, were significantly lower than those of controls.5. Measurement of intracellular potentials in hearts taken from treated rabbits showed that the main effects were a reduction in the maximum rate of depolarization and a prolongation of the plateau of the action potential.6. Guinea-pigs treated for 6 weeks with 15 mg/kg oxyfedrine daily i.p. were protected to some extent from the toxic effect of ouabain infused intravenously.
摘要
先前的急性实验研究表明，奥昔非君的主要药理作用是刺激β-肾上腺素能受体，但也有临床报告称该药物对治疗心绞痛有益。
在本实验中，对兔子和豚鼠进行了为期数周的腹腔注射奥昔非君治疗。
每日15毫克/千克的奥昔非君剂量在4周内对生长速率没有影响，但此后治疗组动物的生长速率低于对照组。
治疗组动物的心脏重量以体重百分比表示，显著低于对照组。
对取自治疗后兔子心脏的细胞内电位进行测量表明，主要影响是去极化最大速率降低和动作电位平台期延长。
每天腹腔注射15毫克/千克奥昔非君，连续治疗6周的豚鼠，在一定程度上受到保护，免受静脉注射哇巴因的毒性作用。
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2
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J Physiol. 1962 Feb;160(2):317-52. doi: 10.1113/jphysiol.1962.sp006849.
3
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Lancet. 1963 Feb 23;1(7278):420-1. doi: 10.1016/s0140-6736(63)92306-7.
4
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J Physiol. 1959 Jun 11;146(3):411-28. doi: 10.1113/jphysiol.1959.sp006201.
5
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6
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